Marie Curie IF applicant in Toxicology-Lipidomics

IDÆA is an environmental science institute devoted to the study of the footprint of the chemical changes our species is imposing on the biosphere. Founded in 2008, IDÆA was envisaged as a new multidisciplinary research institute bringing together a wide range of expertise in environmental science. The institute has demonstrated particular strengths in the analysis of organic pollutants and their impact on ecosystems, the study and management of water resources, the development of multivariate resolution algorithms in chemometrics, and in the study of inhalable particulate matter and toxic gases.

The Environmental Toxicology group is specialized in the combined use of biochemical and chemical tools to evaluate the impact of pollution and human pressure on aquatic ecosystems, with special attention to endocrine and metabolic disrupters. Current research interests include the development and application of alternative in-vitro methods based on the use of fish and human cell lines or isolated subcellular fractions in order to reduce the use of experimental organisms. These techniques have been applied to evaluate the toxicity of drugs, synthetic musks, plasticizers and environmental samples, as well as in studies of endocrine and metabolic disruption. The application of lipidomics analysis to these in-vitro systems constitutes a new research line, whose objective is to develop new biomarkers of metabolic disturbance.

The Environmental Toxicology group (IDAEA-CSIC) is searching for postdoctoral candidates to work on the development of 3D spheroid cultures of fish liver cells as an alternative model to assess the toxicity and metabolism of emerging contaminants, and to develop new biomarkers of metabolic disturbances based on the integration of different -omic thechnologies, including transcriptomics, proteomics and metabolomics.

Candidates should have a strong background in assessing the biological effects of contaminants across different biological levels, ideally using different –omic approaches and interest/experience in alternative in-vitro methods (3D-spheroids). They must meet the requirements of the Marie Curie fellowship.

For more information, please send curriculum vitae and letter of motivation to cinta.porte@idaea.csic.es.